Semax
$49.99
Research-Grade Compound · RUO
Semax Research Peptide
ACTH(4-7) Pro-Gly-Pro neuropeptide analogue studied for BDNF upregulation, neuroprotective signaling, and melanocortin CNS receptor activity in neural cell models
$49.99
10 mgUSD · Research GradeIn stock — ships same or next business day from the United States
Lyophilized, filled and sealed in our U.S. facility from globally sourced peptide. Independently third-party tested, with batch-specific COAs on file.
Purity Guarantee
If any compound falls short of ≥99% purity on its COA, contact us and we'll make it right.
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⚗ Research Use Only. Not for human consumption.
Scientific Context
Research Applications
- 01
Neuroscience researchers investigating brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) expression modulation in neuronal culture systems and ischemia models
- 02
Neuroprotection biology laboratories studying oxidative stress mitigation, mitochondrial function, and neuronal survival signaling under excitotoxic challenge conditions in vitro
- 03
CNS pharmacology scientists examining ACTH-derived peptide activity at melanocortin receptors without adrenal axis activation, for mechanistic receptor subtype research
Observed Mechanisms
In-Vitro Activity Profile
Melanocortin Receptor CNS Activity
Derived from ACTH(4-7), Semax engages central melanocortin receptor subtypes (MC4R, MC5R) without stimulating ACTH-dependent adrenal cortisol secretion, studied as a CNS-selective melanocortin research tool.
BDNF & NGF Transcriptional Modulation
Multiple preclinical studies document Semax-associated increases in BDNF mRNA and protein levels in hippocampal and cortical tissue preparations, with parallel increases in NGF expression reported in neural injury models.
Neuroprotective Pathway Activation
In-vitro neuronal models have associated Semax with reduced markers of oxidative stress and apoptosis under ischemic conditions, examined via caspase-3 activity, ROS quantification, and mitochondrial membrane potential assays.
Related Compounds
Frequently Researched Together
Semax is a synthetic peptide derived from ACTH(4-10). Research applications include studies on BDNF and NGF expression, cerebrovascular function, and neuroprotective mechanisms in cell culture and animal models.
Common Questions